Structural Biology Laboratory

Referents: Prof. Andrea Mattevi, Prof. Claudia Binda

The laboratory is a research hub dedicated to structural biology and enzymology. The team investigates the atomic-level mechanisms of proteins, with a specific focus on metabolons, their regulatory pathways, and their potential for biotechnological applications. By integrating various structural and biochemical methods, they visualize how enzymes catalyze complex reactions and how their dysfunction contributes to diseases like cancer and neurodegeneration. Ultimately, their work bridges fundamental biochemistry with drug discovery, aiming to design targeted inhibitors by deciphering the precise 3D architecture of biological macromolecules.