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Tematiche di ricerca

Attività di ricerca attive, al momento, per gli studenti del Dottorato di Ricerca in Genetica e Biologia Molecolare e Cellulare. Tra parentesi sono riportati i nomi dei supervisori che possono ospitare dottorandi.

Si possono trovare ulteriori informazioni sulle pagine personali di ciascun supervisore.

  • Molecular determinants of virus-host interaction (F. Magnani)
     
  • Structure/function studies of membrane proteins of medical relevance (solute carrier transporters, GPCRs). Membrane protein folding (F. Magnani)
     
  • "Deciphering the crosstalk between cellular metabolism and epigenetics to identify novel anti-cancer strategies" (R. Tricarico)
     
  • Genomics, archaeogenomics and phylogeography of human populations and animal species (mainly livestock and others closely interacting with humans) (A. Achilli, L. Ferretti, A. Olivieri, O. Semino, A. Torroni)
     
  • Ancient DNA assessment of museum and historical specimens (A. Achilli, A. Olivieri)
     
  • Molecular biology, cytogenetics, epigenomics for the study of mammalian centromeres and telomeres and of their involvement in evolution and carcinogenesis (E. Giulotto, S. Nergadze, E. Raimondi)
     
  • Genomics and epigenomics in the study of neurodegenerative disorders in adults and children (C. Cereda)
     
  • Computational Genomics and Bioinformatics to understand the role of genetic variation across multiple Human phenotypes, and to model inflammation as predictor of phenotype evolution (F. Lescai)
     
  • Genomics, metagenomics and physiological assessment of climate adaptation in arboviral vectors and vector competence (M. Bonizzoni)
     
  • Physiological and molecular mechanisms of seed priming; Hallmarks of the seed pre-germinative metabolism (A. Balestrazzi)
     
  • DDR (DNA damage response) mechanisms involving plant TDPs (tyrosyl-DNA phosphodiesterases) and microRNAs; Development of novel approaches to assess seed quality (A. Macovei)
     
  • Functional genomics of insect reproduction; development of metabolomics-based approaches to identify male quality markers for improved fruit fly mass-rearing in pest control programs (F. Scolari, A.C. Croce)
     
  • Studi preclinici cellulari e molecolari di patologie infiammatorie e neoplasie gliali del sistema nervoso centrale ed enterico (S. Comincini)
     
  • Genetics and molecular pathogenesis of ESKAPE and opportunistic bacterial pathogens  (G. Barbieri, S. Buroni)
     
  • Genetic and molecular studies on regulatory mechanisms involved in metabolism and pathogenesis in Gram-positive bacteria (G. Barbieri)
     
  • New therapeutic strategies to fight Multi-Drug Resistant pathogens (S. Buroni)
     
  • Bioinformatic and “-omics” analyses on pathogens and parasites, from evolution to epidemiology (D. Sassera, M. Castelli)
     
  • Integrated evolutionary analyses on bacterial symbionts using genomics, bioinformatics, molecular biology and microscopy (M. Castelli, D. Sassera)
     
  • Viral oncogenesis and the role of T-cell response in controlling the development of virus-associated tumors (F. Baldanti)
     
  • Cellular and molecular studies of the effects induced by platinum compounds and metabolic diseases on the development of the central nervous system (M.G. Bottone)
     
  • Cellular and molecular mechanisms underlying gamete maturation and pluripotent cell differentiation (V. Merico)
     
  • Cytochemical and ultrastructural studies of the nuclear processes of transcript maturation and of the influence of epigenetic modifications (M. Biggiogera)
     
  • Cyto-histochemical studies of normal and pathological tissues and organs, and in experimental conditions (V. Bertone)
     
  • Fluorescence analysis as a tool for investigating biological processes (A.C. Croce, F. Scolari)
     
     
  • Search for new drugs and novel combination regimens against Mycobacterium tuberculosis and non-tuberculous mycobacteria (M.R. Pasca)
     
  • Investigating the molecular and structural properties of human monoamine oxidases (MAOs) to advance drug discovery for neurological diseases and to understand their role in cellular oxidative stress mechanisms (C. Binda)
     
  • Rational and directed protein engineering of enzymes to enhance performance and sustainability in industrial biotechnology (C. Binda)
     
  • Microbial biotechnologies for production of industrially-relevant molecules (C. Calvio)
     
  • Phenotypic and molecular characterization of multidrug-resistant (MDR) bacterial pathogens: study of resistome, virulome, plasmidome and biofilm formation from hospital and environmental settings.  (R. Migliavacca A. Piazza)
     
  • Functional and population genomics of harmful insects for tracking the invasion processes and for the development of control methods; studies on mosquito immunity and vector competence (M. Bonizzoni, L.M. Gomulski, L. Ometto)
     
  • Improving photosynthesis and crop productivity by modulating photoprotective mechanisms (A. Pinnola)
     
  • Study of the molecular mechanisms underlying the response of human cancer and healthy cells to radiation above or at the ionization threshold (O. Cazzalini, P. Perucca)
     
  • Studies on human hereditary disorders, with a special focus on nucleotide excision repair-defective diseases, as model systems to identify molecular pathways relevant for aging, neurodegeneration and cancer (G. Biino E. Botta, D. Orioli, F. Peverali,)
     
  • Molecular characterisation of DNA damage tolerance mechanisms and their involvement in the maintenance of genomic stability (S. Sabbioneda)
     
  • The DNA damage response in cell physiology, cancer progression and rare hereditary diseases (G. Buscemi, L. Zannini)
     
  • Targeting cancer metabolism reprogramming to halt disease progression using in vitro, preclinical, and clinical models (G. Zadra)
     
  • Understanding the crosstalk between diet, metabolic pathways, and tumor microenvironment in promoting cancer progression using pathology transcriptomics, metabolomics, and bioinformatics approaches (G. Zadra)
     
  • Alternative splicing regulation in developmental processes and diseases (G. Biamonti, C. Ghigna)
     
  • Bioinformatics approaches for the genomic and functional characterization of long non-coding RNAs (S. Bione)
     
  • Genome instability mechanisms: identification and functional characterization of markers relevant for tumor development and progression (O. Cazzalini, P. Perucca)
     
  • Cross-talk between DNA and RNA metabolism in response to different stress stimuli, in cancer and neurodegeneration (G. Biamonti, C. Ghigna, S. Francia, G, Liberi, A. Montecucco)
     
  • Understand the genetic/molecular mechanisms regulating cancer development, progression and spreading, to identify novel therapeutic targets with translational potential (N. Pellegata)
     
  • Identify the genetic/molecular basis of cell type-specific drug vulnerabilities to achieve personalized treatments (N. Pellegata)
     
  • An approach based on antibody drug conjugate (ADC) to tackle multidrug resistant tuberculosis (G. Degiacomi)
     
  • Comparative and population genomics in insects (L. Ometto)
     
  • The role of transposable elements in the evolution and adaptation of mosquitos (L. Ometto)
     
  • Advanced 3D Skin Models for the Study of DNA Repair Defects, Skin Cancer, Aging, and Therapeutic Discovery  (M. Lanzafame)
     
  • Organelle Communication in Cellular Homeostasis and Neurodegenerative Diseases (P. Colombi)
     
  • "Dissecting nucleic acid immunity in gene therapy and disease" (A. Kajaste)