Molecular Mechanisms of Innate Immunity and Nucleic Acid Sensing

Referent: Prof. Anna Kajaste-Rudnitski

Co-workers: Carolina Petrillo (Post-Doc), Alessandro Mapelli (PhD student), Giovanni Crivicich (PhD student), Silvia Piccolo (PhD student), Radu Marian Rivara (Lab manager)

The AKR Lab studies the molecular mechanisms of host-vector interplay and innate immunity in the
context of gene therapy and investigates these pathways in the context of pathological conditions of
the central nervous systems and autoimmune diseases. The long-term goal is to provide insight into
how pathogen recognition and consequent innate immune signalling may affect efficacy and safety
of gene therapy approaches in clinically relevant target cells as well as to shed light on how these
same pathways may contribute to autoimmune and inflammatory pathologies.